Description
Chemical Identity
HGH 191aa (Somatropin) is recombinant human growth hormone, a 191-amino acid single-chain polypeptide with the molecular formula C990H1529N263O299S7 and a molecular weight of approximately 22,124 Da (CAS number 12629-01-5). The protein is structurally identical to endogenous pituitary-derived somatotropin, featuring a four-helix bundle structure stabilized by two disulfide bonds (Cys53-Cys165 and Cys182-Cys189).
Human growth hormone is produced by somatotroph cells of the anterior pituitary gland and is the principal regulator of postnatal longitudinal growth. Beyond growth, HGH 191aa plays critical roles in body composition, metabolic regulation, bone density, and immune function throughout the lifespan.
| Property | Value |
|---|---|
| Molecular Formula | C990H1529N263O299S7 |
| Molecular Weight | ~22,124 Da |
| CAS Number | 12629-01-5 |
| Structure | 191 amino acid single-chain polypeptide; four-helix bundle |
| Research Status | FDA-approved (multiple indications) |
Research Overview
HGH 191aa is one of the most extensively studied hormones in biomedical research, with FDA approval for growth hormone deficiency in both children and adults, Turner syndrome, chronic renal insufficiency, Prader-Willi syndrome, and other growth-related conditions. The primary mechanism involves binding to the growth hormone receptor (GHR) on target cells, activating the JAK2-STAT5 signaling pathway, and stimulating hepatic production of insulin-like growth factor-1 (IGF-1), which mediates many of the growth-promoting effects.
HGH 191aa acts through both direct effects (lipolysis, protein synthesis, gluconeogenesis) and indirect effects mediated through IGF-1 (longitudinal bone growth, cellular proliferation, anabolic metabolism).
Key areas of published research include:
- Growth Hormone Deficiency: Extensive clinical trial evidence supports the use of recombinant HGH for growth hormone deficiency in both pediatric and adult populations, with well-characterized dose-response relationships and long-term safety data spanning decades of clinical use.
- Body Composition and Metabolism: HGH 191aa has been studied for its effects on lean body mass, fat distribution, bone mineral density, and metabolic parameters. Growth hormone promotes lipolysis and protein synthesis while having complex effects on glucose metabolism.
- Age-Related GH Decline: Research on somatopause (the age-related decline in GH/IGF-1) has generated interest in understanding the role of GH in aging, body composition changes, and functional decline in older adults.
HGH 191aa is a well-characterized pharmaceutical with extensive regulatory approvals and clinical experience. Research-grade material is used for in vitro and preclinical studies.
Specifications
All HGH 191aa supplied by Prescott Bio Canada is manufactured to research-grade standards.
| Specification | Detail |
|---|---|
| Purity | >98% (HPLC) |
| Form | Lyophilized powder |
| Appearance | White to off-white powder |
| Storage (lyophilized) | -20°C, protected from light |
| Storage (reconstituted) | 2-8°C, use within 30 days |
| Solubility | Soluble in sterile water or appropriate buffer |
Each vial is accompanied by a Certificate of Analysis (COA) documenting purity, identity, and endotoxin testing.
Research Applications
HGH 191aa is supplied exclusively for in vitro and in vivo laboratory research. Published experimental applications include:
- Growth hormone receptor signaling and JAK2-STAT5 pathway studies
- IGF-1 axis research and hepatic growth factor production
- Body composition and metabolic regulation studies
- Bone metabolism and mineral density research
- Somatopause and age-related GH decline research
- Growth factor biology and cellular proliferation studies
Researchers should consult the primary literature and institutional review protocols before designing experiments with HGH 191aa.
Storage and Handling
Lyophilized powder: Store at -20°C in the original sealed vial, protected from light and moisture. Under these conditions, HGH 191aa maintains stability for up to 24 months.
Reconstituted solution: Reconstitute with sterile water or appropriate buffer to the desired concentration. Gently swirl to dissolve — do not vortex, as the large protein structure is susceptible to denaturation. Store reconstituted HGH 191aa at 2-8°C and use within 30 days. Avoid repeated freeze-thaw cycles.
Handling precautions: This product is intended for research use only (RUO). Not for human or veterinary diagnostic or therapeutic use. Handle using standard laboratory safety practices including appropriate PPE.